BRCA1 and breast cancer: Results from 28 studies estimated that the risk of developing female BC by age 70 years is 55–72% for BRCA1 P/LPV carriers and 45–69% for BRCA2 P/LPV carriers; the lifetime risk of developing OC is 39–44% for BRCA1 P/LPV carriers and 11–17% for BRCA2 P/LPV carriers [4].