CDC45 and craniosynostosis: Recently, in patients with 22q11.2DS, the alteration of CDC45 was associated with the pathogenesis of craniosynostosis, as well as phenotypic features more frequently reported in association with Baller–Gerold (OMIM 218600) and RAPADILINO syndrome (OMIM 266280), as well as unique previously-unreported features [26].