In laryngeal carcinoma, PRMT5 regulates WNT4 expression, and PRMT5–WNT4 activates β-catenin to induce cadherin 2 (CDH2: also known as N-cadherin) and SNAIL expression, which is involved in EMT and promotes cell migration and lymph-node metastasis [65] (Figure 54). The gene discussed is CDH2; the disease is laryngeal carcinoma.