Results of a large human genetics study consisting of 58,335 participants (13,102 patients with coronary artery disease (CAD) and 40,430 controls) reported that ANGPTL3 loss-of-function variants were associated with 41% lower odds of CAD (adjusted OR 0.59, 95% CI 0.41–0.85; p = 0.004) [27]. Here, ANGPTL3 is linked to coronary artery disorder.