Based on the results of 12 different studies including 20,000 participants, Khera et al. (2016) demonstrated a 22-fold increased risk for CAD in patients with an LDL-C ≥ 190 mg/dL (4.9 mmol/L) plus an FH-causing variant when compared to individuals without an FH-causing variant and an LDL-C below 130 mg/dL ((3.4 mmol/L), OR 22.3, 95% CI 10.7–53.2) [32]. This evidence concerns the gene FH and coronary artery disorder.