Intronic variants in MYBPC3 in the context of hypertrophic cardiomyopathy have also been identified [14,15,16] and, in the last few years, have focused on one specific intronic MYBPC3 variant c.1224-52G>A (IVS13-52G>A) [17,18,19,20,21]. The gene discussed is MYBPC3; the disease is hypertrophic cardiomyopathy.