Currently, there are very limited studies linking hypertrophic cardiomyopathy with pathogenic variants in MYBPC3 to mitochondrial abnormalities and mitochondrial dysfunction [53], and this specific variant c.1224-52 G>A, to our knowledge, was not linked previously to mitochondrial abnormalities and/or dysfunction. This evidence concerns the gene MYBPC3 and hypertrophic cardiomyopathy.