All of the SDH genes are involved in the tumorigenesis of different types of cancers including GIST, paraganglioma, pheochromocytoma, chronic lymphocytic leukemia, renal cell carcinoma, thyroid cancer, Hodgkin lymphoma, pituitary adenomas, and neuroendocrine tumors of the pancreas [18,19,20,21,22]. Here, SDHB is linked to paraganglioma.