The genetic markers of thrombophilia in our study were heterozygous Leiden mutations in the FV gene and G20210A in the FII gene (corresponding homozygous mutations were not found in patients); homozygous C677T and A1298C mutations in the MTHFR gene and 4G/5G in the PAI-I gene; and hetero- and homozygous forms of C494T mutation. This evidence concerns the gene MTHFR and Rare hereditary thrombophilia.