The regulatory action of Zeb2 on the Tcf4 target gene, as found in mouse cells by our ChIP-seq, may underpin phenotypic similarities between MOWS and Pitt-Hopkins syndrome patients (PTHS, OMIM #610954; for a recent discussion, see [57]) the latter caused by mutations in TCF4 [58], making us speculate that TCF4 may be deregulated in neural cells in MOWS. Here, ZEB2 is linked to Pitt-Hopkins syndrome.