GDF5 and cancer: The hub transcription factors IRX3, NKX6-2, PTGER3 and SMAD5 were identified (by in silico analysis) to regulate target genes and may participate in EBVaGC pathogenesis by regulating important genes such as SST (Somatostatin), an important regulator of motor activity and the secretion of gastrin-stimulated gastric acid in the gastrointestinal tract [103], and GDF5 (growth differentiation factor 5), a regulator of differentiation and cell growth in both embryonic and adult tissues, whose aberrant expression is related to cancer [104,105,106,107].