Notwithstanding, Zhi and colleagues [89] found that another epigenetic mechanism can be a regulator of IRX1: in a study involving several GC cell lines, they identified that oncogenic miRNA-544 directly targets the 3′-UTR of IRX1 and that its overexpression causes inactivation and low expression of IRX1 protein. This evidence concerns the gene IRX1 and gastric cancer.