In light of the pivotal role of vWF and its processing peptidase ADAMTS13 in the development of COVID-19 associated coagulopathy, we aimed to explore whether certain missense polymorphisms of these genes can modulate (and predict) the severity and progression of COVID-19 by attenuating ADAMTS13 activities or stabilizing vWF. Here, ADAMTS13 is linked to blood coagulation disease.