Studies have since suggested that locus-specific methylation may be more important than overall methylation status, with Zhao et al. identifying specific epigenetic changes within the TERT promoter or partial exon 1 region, associated with leukaemia, which may alter the secondary or tertiary structure of the region, modifying their potential to form interactions with transcription factors and, therefore, regulating TERT expression [161]. The gene discussed is TERT; the disease is leukemia.