Moreover, increased MTHFR promoter methylation results in decreased MTHFR gene expression levels and has been associated with preeclampsia [55], recurrent miscarriages [56,57], trisomy 21 and congenital heart defects in the offspring [58,59] as well as with male infertility, likely inducing impaired methylation in sperm cells [60,61]. The gene discussed is MTHFR; the disease is male infertility.