When tested in a leukemia cell line, TALE:KDM1A was able to target an active H3K4me2+ and H3K27ac+ enhancer of the SCL gene (encoding for a transcription factor with critical function in hematopoiesis), and to significantly reduce histone methylation and acetylation, and as a consequence, SCL expression [124]. The gene discussed is TAL1; the disease is leukemia.