Our results suggest that a 13 gene signature (COL6A3, COL1A2, MFAP5, DCN, PDGFRB, LUM, IGFBP4, EMILIN1, CCDC80, FAP, CDH11, THBS2, and ELN) is altered in in vitro and in vivo HIBM models as well as in many other muscular disorders. This evidence concerns the gene DCN and muscle tissue disorder.