Our results suggest that a 13 gene signature (COL6A3, COL1A2, MFAP5, DCN, PDGFRB, LUM, IGFBP4, EMILIN1, CCDC80, FAP, CDH11, THBS2, and ELN) is altered in in vitro and in vivo HIBM models as well as in many other muscular disorders. Here, FAP is linked to muscle tissue disorder.