Furthermore, based on PICKLE meta-database PPI data, five nodes, FMR1, FAM161A, APP, SQSTM, PIK3R1, which are well-connected with at least two “non-spliceosomal” FRA10AC1 interactors (Table S1), reveal the additional important correlations of the FRA10AC1 network with severe well-described neurodevelopmental and neurodegenerative diseases including Fragile X syndrome, Alzheimer’s disease, cerebral amyloid angiopathy, amyotrophic lateral sclerosis, and SHORT syndrome (Figure 4, Table 1). Here, PIK3R1 is linked to neurodegenerative disease.