Here, we found that the genes TDRD5, SOHLH1, MCIDAS, and ZPBP were abnormally expressed in the testes of obese monkeys compared with normal-weight controls, suggesting that the dysfunction of those genes and their related biological functions should be given prominence in studies of human obesity-induced male infertility. The gene discussed is TDRD5; the disease is obesity due to melanocortin 4 receptor deficiency.