AGER and COVID-19: Among the 344 down-regulated genes, the top 20 KEGG pathways included coronavirus disease-COVID-19, chemokine signaling pathway, thyroid hormone signaling pathway, long-term depression, ribosome, Interleukin (IL)-17 signaling pathway, circadian entrainment, advanced glycation end products- receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications, tyrosine metabolism, RIG-I-like receptor signaling pathway, estrogen signaling pathway, and others (Figure 6B).