HMPOS-2.5 exhibited upregulation of THBS1, SFRP2, PTN, FSIP1, DPT, OMD, OGN, COL5A2, and ENO1 and downregulation of PIEZO2, IGFBP2, and ACVR2A. This evidence concerns the gene PIEZO2 and occult macular dystrophy.