HMPOS-2.5 exhibited upregulation of THBS1, SFRP2, PTN, FSIP1, DPT, OMD, OGN, COL5A2, and ENO1 and downregulation of PIEZO2, IGFBP2, and ACVR2A. The gene discussed is SFRP2; the disease is occult macular dystrophy.