Nonetheless, two separate studies reported otherwise, showing that the low expression of DNMT3A, DNMT3B, MBD2 and MBD4 in ITP and the hypomethylation of MBD2 and MBD4 may play an equally important role in the progression of ITP [36]. The gene discussed is MBD4; the disease is autoimmune thrombocytopenic purpura.