The genetic abnormalities leading to PMS are also relatively heterogeneous, ranging from pathogenic variants of the SHANK3 gene to terminal deletions of the 22q13 region spanning over 9 Mb, and including chromosomal rearrangements such as ring chromosome 22, unbalanced translocations, and interstitial deletions [1,5,6,7,8]. The gene discussed is SHANK3; the disease is premenstrual tension.