Nevado et al. (2022) identified a region of 4.5 to 8 Mb from the telomere as associated with macrocephaly and a region of 0.4 to 3.4 Mb from the telomere associated with microcephaly and suggest GRAMD4 as a dosage-sensitive gene that may be involved in macrocephaly [3]. This evidence concerns the gene GRAMD4 and microcephaly.