MUC1 and digestive system cancer: The significance of the present study lies in (1) the use of MUC1.Tg mice who express de novo MUC1 as a self-antigen and have been reported to be tolerant to MUC1 [43], (2) the use of an inflammation-induced colon cancer model that closely resembles the colon carcinogenesis process seen in humans, and (3) the use of DCs to enhance the anti-tumor immune response.