BRCA1 and breast cancer: Similarly, the CARRIERS population-based study examined pathogenic variants in predisposition genes and risk of breast cancer in women < 45 years of age and reported the strongest association between BRCA1 (OR = 8.63; 95% CI: 5.63–13.89; p < 0.001) and BRCA2 (OR = 7.65; 95%CI: 5.47–11.02; p < 0.001), and the risk of developing breast cancer before the age of 45 years (Table 1) [119].