Multivariate analysis in a retrospective study including 739 women <40 years of age out of 7105 participants showed that HER2+ tumours (OR = 1.82), nodal involvement (OR = 1.69), histologic grade (grade 3 OR = 1.41), and tumour size (T2 OR = 1.37; T3–T4, 1.47) were independently associated with younger age at diagnosis [208]. This evidence concerns the gene ERBB2 and neoplasm.