BRCA1 and breast carcinoma: A recent study by the Breast Cancer Association Consortium that examined the risk of breast cancer for protein-truncating germline variants in nine genes found the highest breast cancer risk for age <40 years associated with BRCA1 (OR = 32.8; 95% CI: 16.9–63.4) and BRCA2 (OR = 11.9; 95% CI: 7.33–19.4) [118].