Moreover, in patients with chronic HIV infection, which results in CD4 T-cell loss and reduced anti-viral function of CD8 T and NK cells, uncontrolled proliferation of EBV-infected lymphocytes may occur; accordingly, most HIV-associated LPDs display a plasma cell phenotype and are linked to EBV infection [33]. The gene discussed is CD8A; the disease is Epstein-Barr virus infection.