A pathological response to EBV infection occurring in adolescents and young adults is infectious mononucleosis (IM), a self-limiting disease mainly characterized by prolonged fever, hepatosplenomegaly, lymphadenopathy, and CD8 T-cell lymphocytosis; in addition, IM has been linked to the increased risk of developing Hodgkin’s lymphoma (HL) and multiple sclerosis (MS) [25]. Here, CD8A is linked to Epstein-Barr virus infection.