Furthermore, unspecified NKG2DLs were detected by means of recombinant NKG2D-Fc staining on LCLs generated from healthy individuals or XMEN patients; importantly, NK and CD8 T cells with low NKG2D expression isolated from XMEN patients poorly recognized autologous LCLs unless effectors were previously exposed to Mg2+, which resulted in NKG2D up-modulation [46]. The gene discussed is KLRK1; the disease is X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia.