In addition, other IEIs affecting innate and/or adaptive immune cells and predisposing to multiple viral and non-viral infections may result in severe EBV infection, including mutations in GATA2, MCM4, FCGR3A, CARD11, ATM, and WAS [40,41,42,43,44,45]. This evidence concerns the gene MCM4 and Epstein-Barr virus infection.