Recently, in a large cohort of adult SOT recipients, both NK and T cells were analyzed, comparing patients diagnosed with EBV+ PTLD, EBV− PTLD, and control PTLD-free transplanted patients [71]; this study showed that EBV+ PTLD patients presented a profound NK cell lymphopenia, a higher proportion of PD-1+ NK cells associated with EBV viral load, and EBV-specific CD8 T reduced in number and functionally exhausted. The gene discussed is CD8A; the disease is post-transplant lymphoproliferative disease.