The methylation level of cg19724470 in the NSCLC tumors more closely resembled an on-off switch for PD-L1 expression, as cg19724470 methylation of the tumors with PD-L1 TPS ≥ 1%, in general, was lower compared to the methylation observed in tumors with PD-L1 TPS < 1%. This evidence concerns the gene CD274 and non-small cell lung carcinoma.