To mimic the oncogenic spectrum observed in NSCLC patients, we analyzed 14 NSCLC cell lines with different oncogenic mutations, including hotspot mutations in EGFR, KRAS, tumor protein P53 (TP53), and phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA). This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.