In addition, one study that assessed an endometrial dedifferentiated carcinoma molecular profile suggested that POLD1 and MLH1 (a gene involved in DNA mismatch repair), as well as high microsatellite instability (MSI-H) and increased tumor mutation burden (TMB), may be peculiar to this rare distinct subtype of EC [68]. The gene discussed is POLD1; the disease is neoplasm.