ESR1 and metastatic malignant neoplasm in the lymph nodes: Cytoplasmic HSP70 immunoreactivity was significantly correlated with the stage, pathological T factor, lymph node metastasis, histological grade, and Ki67 LI, while it was negatively correlated with ER and PR, suggesting the aggressive roles played by cytoplasmic HSP70 in breast cancer, similarly to a previous study [74].