Although the role of extracellular HSP70 in the tumor microenvironment is not yet fully understood, it has been reported to activate neutrophils through Toll-like receptor (TLR) 2/4 and to cause the production of reactive oxygen species and the release of IL-8, promoting tumor angiogenesis and metastasis [25,26,27]. Here, CXCL8 is linked to neoplasm.