CHEK1 and non-small cell lung carcinoma: Similarly, ESA+CD24+CD44+ pancreatic CSCs and NSCLC sphere cultures exhibited augmented ATR-mediated CHK1 phosphorylation compared to non-stem cell counterparts and combination therapy of CHK1 inhibition with gemcitabine or cisplatin increased DNA damage conferring CSC chemosensitivity [153,154].