Inhibition of WEE1 was shown to sensitise trastuzumab-resistant BCSCs to chemotherapy-induced apoptosis, and co-administration of an ATR and WEE1 inhibitor showed an elevated synergistic cytotoxic effect in BCSCs isolated from an orthotopic breast cancer xenograft mouse model [158,159]. The gene discussed is WEE1; the disease is breast carcinoma.