CD4 and neoplasm: For example, Parhi et al. [10] found that Fn colonizes breast tumors and causes a decrease in CD4+ and CD8+ T cells through the abundant Gal-GalNAc (also known as Thomsen-Friedenreich antigen) on tumor cells, so it is reasonable to speculate that Fn not only inhibits NK cells and tumor-infiltrating T cells killing of cancer cells [64], but also inhibits the accumulation of tumor-infiltrating T cells and promotes tumor growth and metastatic progression.