Yue et al. [58] found that metabolite secretion of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway, and in Caco-2 cells, MMP-2, MMP-9, and VEGFA gene expression was significantly reduced in the YYC-3-treated group. This evidence concerns the gene VEGFA and malignant colon neoplasm.