However, concomitant treatments with drugs such as vascular endothelial growth factor (VEGF) inhibitors, or the simple presence of cancer itself (capable of triggering hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP)), do not allow us to draw definitive conclusions on the association between ICI-AKI and TMA [38,39]. The gene discussed is VEGFA; the disease is thrombotic thrombocytopenic purpura.