THBS1 and glioblastoma: Syndecan-1 is a key molecule in the motility of cells; it is crucial in coupling the organization of fascin spikes in response to a physiological extracellular ligand, TSP-1, and an overexpression of syndecan-1 in a heterologous cell type is sufficient for causing a dramatic enhancement of cell spreading and formation of fascin spikes in response to TSP-1. It is significantly expressed by GBM cells.