In addition to previous work elucidating the oncogenic functions of IKKβ in tumor cells [6,11,22,34,53,65,66], here we show how myeloid IKKβ functions to fuel tumor cell NF-κB signaling with IL-1β, further emphasizing the complex and multifaceted pro-tumor functions of NF-κB and the need for its therapeutic targeting against cancer. This evidence concerns the gene NFKB1 and neoplasm.