VCAN and cancer: VCAN overexpression is not restricted to mouse KrasMUT cancers, since VCAN transcripts are also over-represented in human cancers with high KRASMUT frequencies (derived from the catalogue of somatic mutations in cancer, COSMIC), such as LUAD from smokers (GEO dataset GSE43458), and NSCLC and colorectal adenocarcinoma (COAD/READ; GEO dataset GSE103512) (Figure S14A,B) [58,59,60].