KRAS and cancer: We next analyzed TCGA pan-cancer transcriptome data to discover that IL1B mRNA levels were elevated in KRASMUT and amplified cancers, and performed IL-1β immunohistochemistry in our own patients with resected LUAD [13] to find increased IL-1β protein expression in KRASMUT LUAD compared with KRAS-wild-type (WT) LUAD and adjacent lung tissues (Figure 1C,D).