HMGB1 and colorectal carcinoma: As HMGB1 can act as a damage associated molecular pattern in the extracellular space to modulate immune responses, we next focused our attention back to the CRC TMA (n = 650, Supplementary File S1) to assess whether epithelial HMGB1 expression was associated with the tumour immune microenvironment (Table 2 and Figure 4).