SSTR2 and neoplasm: In vitro models and human samples from NENs expressing SSTR2 have shown that the DNA damage and apoptosis induced during PRRT are heterogeneous and significantly correlated with SSTR2 expression, with higher damage observed in areas of the tumour with a high expression of the target receptor, this was not explained by differences in proliferation nor in bioavailability of the radioligand [48].