The expression of SSTRs on imaging could therefore be more accurate in the assessment of tumour heterogeneity in comparison to tumour sampling (i.e., assessment of Ki-67 on tumour biopsy), as imaging can assess all primary and secondary lesions (spatial and morphological heterogeneity), and can be repeated to assess changes in tumour biology over time (temporal heterogeneity) [52]. This evidence concerns the gene MKI67 and neoplasm.