A large molecular profiling study on SI neuroendocrine liver metastases showed that the expression of several cancer-related pathways that promote tumour development, progression and angiogenesis, including phosphoinositide 3 kinase (PI3K), epidermal growth factor receptor (ErbB1), platelet-derived growth factor receptor beta (PDGFRβ) and mTOR, is upregulated in neuroendocrine liver metastases in comparison to their primary site, and that neuroendocrine liver metastases harbour progressive genomic aberrations that occur mostly during the metastatic progression of the tumour [43]. The gene discussed is MTOR; the disease is cancer.