Thus, it is conceivable that senescent cells also support the collective invasion and the metastatic process in breast carcinomas through their SASP in a manner similar to that observed in papillary thyroid carcinomas, in particular in breast cancer subtypes with a high incidence of senescent tumor cells such as luminal A and HER2+ [38]. Here, ERBB2 is linked to thyroid gland papillary carcinoma.