Additionally, the proliferative nature of RT-DLBCL could also be due to disruptions in the MYC network, with MYC mutations occurring in 30% of cases of clonally related RT-DLBCL [19] and NOTCH1 mutations occurring in 30% of cases of clonally related RT-DLBCL [32]. The gene discussed is NOTCH1; the disease is diffuse large B-cell lymphoma.