Mutations in TP53, NOTCH1, MYC and deletions in CDKN2A (cyclin-dependent kinase inhibitor 2A), as well as the preferential use of the 8th subset of stereotyped immunoglobulin heavy chains (IGHV4-39/IGHD6-13/IGHJ5), also seem to be more prevalent in clonally related RT-DLBCL [7,19,31,32,33]. This evidence concerns the gene NOTCH1 and diffuse large B-cell lymphoma.