The main blood biomarkers of cachexia found in these studies were pro-inflammatory proteins (CRP, IL-6, IL-8, IL-10, IFNγ, TNFα), members of the TGFβ family (myostatin, activin), tumor-derived factors (ZAG, midkine), markers of lipolysis (leptin, adiponectin), and other proteins such as IGF-1, albumin, and angiotensin II. This evidence concerns the gene LEP and Cachexia.