NFKB1 and squamous cell carcinoma: The same mechanism was confirmed by in vivo experiments on mice, demonstrating that selective inhibition of NF-κB suppresses bone invasion in a model of mandibular invasion by OSCC [51], more specifically, over a period of 3 weeks, using a model of mandibular invasion by squamous cell carcinoma cell line (SCCVII cells), injected three times a week with NF-κB essential modulator binding domain (NBD peptide), or control (a mutant NBD peptide) [52].