Some genes of heat shock protein (HSP) have been found in the TNF-α gene region that increase the expression of this protein on the keratinocyte surface and it heralds the role of TNF-α in OLP [103]; oral keratinocytes release multiples of pro-inflammatory cytokines such as TNF-α that contribute at different stages of OLP pathogenesis. The gene discussed is HSP90B2P; the disease is oral lichen planus.