In a large study which sought to identify genetic variants in the HLA class II region associated with the risk of cSCC, the authors found that cSCC risk was associated with rs28535317 (OR = 1.20, p = 9.88 × 10−11), which corresponded to an amino-acid change from phenylalanine to leucine at codon 26 of HLA-DRB1 (OR = 1.17, p = 2.48 × 10−10). The gene discussed is HLA-DRB1; the disease is skin squamous cell carcinoma.