Of these, six proteins including ISG15, APOA1, MARCKS, EFHD2, STMN1, and ACBD3 were increased and six proteins including DMKN, APCS, CPA3, KRT79, CST6, and CMA1 were decreased in metastatic cSCC compared to the primary lesions [59]. This evidence concerns the gene MARCKS and skin squamous cell carcinoma.