A. Azimi et al. identified 5037 proteins across primary and metastatic cSCC samples, of which 19 proteins, including ISG15, APOA1, and MARCKS, which have roles in metastasis, were increased and 11 proteins, including DMKN, APCS, and CST6, were decreased in metastatic cSCC lesions relative to the primary phenotypes (adj. The gene discussed is ISG15; the disease is skin squamous cell carcinoma.