ZMIZ1 gene expression significantly increased within cSCC genomes (100-300× normal expression levels). High expression associated with poor outcomes in human cSCC patients, correlation threshold of 0.65 (Cox Proportional Hazards Regression, p = 0.0195; Log-rank Test, p = 0.028 at 50% quintile). This evidence concerns the gene ZMIZ1 and skin squamous cell carcinoma.