Moreover, AK144841 was found to inhibit gene expression, specifically downregulating the expression of genes of the Lce1 family, which is involved in epidermal terminal differentiation, and of anticancer genes (including Cgref1, Brsk1, Basp1, Dusp5, Btg2, Anpep, Dhrs9, Stfa2, Tpm1, SerpinB2, Cpa4, Crct1, Cryab, Il24, Csf2, and Rgs16), contributing to the dedifferentiation of tumor-forming keratinocytes, as well as molecular cascades involved in cSCC development [44]. This evidence concerns the gene CGREF1 and neoplasm.