TP53 and head and neck squamous cell carcinoma: In OSCC-derived EVs, circRNA proved to be stably present in abundance [146], to be oncogenic through the upregulation of certain circRNAs in HNSCC, such as circCORO1C via the let-7c-5p/PBX3 axis [147], circRNA MTCL1 by inhibiting C1QBP ubiquitin degradation and beta-catenin activation [148], circPARD3 in autophagy through the PRKCI-Akt-mTOR pathway [149], and circPVT1 via the p53/YAP/TEAD transcription-competent complex [150].