You et al. explained that HS1-associated protein X-1 (HAX-1) was overexpressed in many human malignancies, such as HNSCC and especially NPC [176], and they also announced that exosome-packaged HAX-1 had a better performance when serving as a biomarker for LNM, clinical stage, and the prognosis of NPC [177]. The gene discussed is HAX1; the disease is head and neck squamous cell carcinoma.