However, when we transiently transfected SK-N-BE(2)-C and Kelly cells with two GATA2-specific siRNAs for 96 h, in comparison with siRNA controls, the siRNA knock-down of GATA2 caused a further decrease in cell viability after 72 h in #5333 and #5338 treated cells, suggesting that GATA2 may be regulated by MYCN/PA2G4 and the further reduction of the residual GATA2 by siRNAs, in the neuroblastoma cells treated with the compounds, suppressed the cell viability additively (Figure 5B–D and Supplementary Figure S5G). This evidence concerns the gene GATA2 and neuroblastoma.