PA2G4 and neuroblastoma: However, when we transiently transfected SK-N-BE(2)-C and Kelly cells with two GATA2-specific siRNAs for 96 h, in comparison with siRNA controls, the siRNA knock-down of GATA2 caused a further decrease in cell viability after 72 h in #5333 and #5338 treated cells, suggesting that GATA2 may be regulated by MYCN/PA2G4 and the further reduction of the residual GATA2 by siRNAs, in the neuroblastoma cells treated with the compounds, suppressed the cell viability additively (Figure 5B–D and Supplementary Figure S5G).