UMPS and asthenia: Pellicer et al. (European ancestry; Spain) reported that the C allele of the UMPS rs4678145 SNP (c.156+607G>C; intron) was associated with a higher risk of severe asthenia (OR = 4.54; 95% CI = 1.55–13.24; p = 0.006 for CG/CC vs. GG), and that the C allele of the UMPS rs2279199 SNP (c.-67T>C; 2KB upstream) showed a protective effect against severe nausea and vomiting (OR = 0.21; 95% CI = 0.04–0.90; p = 0.036 for CT/CC vs. TT) in 301 patients with CRC (stages I–IV) treated with capecitabine-based therapeutic regimens [25].