DPYD and Hand-foot syndrome: The rs12132152 SNP (97523004G>A) in LD with rs76387818 (g.97539400G>A), an intergenic SNP located 22 kb downstream of DPYD gene was also associated with severe overall toxicity (OR = 3.83; 95% CI = 3.26–4.40; p = 4.31 × 10–6 and OR = 4.05; 95% CI = 3.47–4.62; p = 2.11 × 10–6, respectively, both for A vs. G) and severe HFS (OR = 6.12; 95% CI = 5.58–6.76; p = 3.29 × 10–8 and OR = 6.44; 95% CI = 5.79–7.09; p = 1.75 × 10–8, respectively, both for A vs. G) [21].