Pellicer et al. (European ancestry; Spain) reported that the CC genotype of the TYMS rs2853741 SNP (c.-391T>C; 2KB upstream) showed a protective effect against severe diarrhea in 301 patients with CRC (stages I–IV) undergoing treatment with capecitabine-based regimens (OR = 0.31; 95% CI = 0.13–0.74; p = 0.008 for CC vs. CT/TT) [25]. The gene discussed is TYMS; the disease is colorectal carcinoma.