ENOSF1 and Hand-foot syndrome: Patients carrying the A allele of the ENOSF1 rs2741171 SNP (c.63+5783A>G; intron) showed an increased risk of overall toxicity and severe HFS (OR = 1.60; 95% CI = 1.39–1.80; p = 6.64 × 10–6 and OR = 1.74; 95% CI = 1.51–1.97; p = 1.64 × 10–6 respectively, both for A vs. G) [21].