This study also reported a significant association of the rs2790 SNP (c.*89A>G; 3′UTR/intron) in the TYMS/ENOSF1 region with grade 2–3 HFS (OR = 0.58; 95% CI = 0.39–0.87; p = 8.80 × 10–3 for AA vs. AG vs. GG) [32]. The gene discussed is TYMS; the disease is Hand-foot syndrome.