This IgG3 antibody exhibits antitumor activity in mouse models of disseminated human multiple myeloma (MM) using SCID-Beige mice challenged intravenously (i.v.)with KMS-11 or ARH-77 cells [23,24] and in a mouse model of AIDS-NHL using NOD-SCID mice challenged intraperitoneally (i.p.)with 2F7 human BL cells [25]. The gene discussed is IGHG3; the disease is non-Hodgkin lymphoma.