As it is well-established that pro-inflammatory stimuli during chronic pancreatitis can lead to ductal hyperplasia and induce acinar-to-ductal metaplasia, which is strongly associated with progression to pancreatic adenocarcinoma [35], we investigated the expression of the ductal markers CK7 and CK19 in healthy and CDE-treated wildtype and Fn14 KO mice. The gene discussed is TNFRSF12A; the disease is pancreatic adenocarcinoma.