Interestingly, the pancreata of 6-month CDE-treated Fn14 KO mice showed only mild signs of pancreatitis and were closer in appearance to the healthy controls than to their chronically injured wildtype counterparts, further underlining the potential relevance of TWEAK/Fn14 signalling during chronic pancreatitis (Figure 2A–D). This evidence concerns the gene TNFSF12 and chronic pancreatitis.