TNFRSF12A and chronic pancreatitis: As PAAD may be a sequela of pancreatitis, we further interrogated publicly accessible data of the murine caerulein model (https://ncbi.nlm.nih.gov, accessed on 1 April 2022; datasets GSE119844 for acute pancreatitis and GSE169525 for chronic pancreatitis) and found that TNFRSF12A expression was low in healthy pancreas tissue and highly upregulated in acute and chronic caerulein-induced pancreatitis (Figure 1C).