Publicly available datasets from The Cancer Genome Atlas (TCGA Research Network, https//www.cancer.gov/tcga, accessed on 1 April 2022) demonstrated that TNFRSF12A is strongly expressed in human pancreatic adenocarcinoma (PAAD) patients (n = 179), with a significantly lower expression in patient-matched non-tumorous pancreas tissue (n = 171), suggesting that Fn14 plays a role in PAAD biology (Figure 1A). The gene discussed is TNFRSF12A; the disease is pancreatic adenocarcinoma.