As detected by qPCR, significantly increased mRNA expression levels of CXCL1, CXCL2, CCL5, CXCL10, and IFN-β were detected in tumor tissues isolated from the shIDH3α + CDDP + PD-L1 group compared to the control+CDDP+PD-L1 and shIDH3α groups (Figure 7J). This evidence concerns the gene IFNB1 and neoplasm.