As expected, RUNX1T1, POU4F1, CACNA2D2, FBLN5, and CAV1 were among the top upregulated genes in RUNX1/RUNX1T1 AML patients, followed by CLEC2L, SIPA1L2, GPM6B, CD19, IL5RA, PALM, ITGB4, FAM81A, SLCO5A1, ROBO1, FOXL1, and TRH (Table S1 and Figure 2). The gene discussed is ITGB4; the disease is acute myeloid leukemia.