To gain a better understanding of the regulatory functions of the RUNX1/RUNX1T1 fusion oncogene in the transcriptome of AML patients of different age groups, we investigated the upstream regulators of the differentially expressed genes (DEG) in two independent GEO datasets composed of adult and pediatric AML patients harboring the RUNX1/RUNX1T1 fusion. Here, RUNX1 is linked to acute myeloid leukemia.