SMC3 and acute myeloid leukemia: Considering the commonly deregulated genes between the two AML datasets, we found that RUNX1, INPPL1, MAPK1, SMC3, TP53, ERG, CDK4, ADCY7, CDK1/2, and ADARB1, among others, were significantly upregulated in the adult AML cohort (TCGA-LAML); whereas ELF1, FOSL2, IGBP1, STAT3, SRF, EZH2, NFE2L2, ATF2, SUZ12, IRF1, CTCF, UQCRQ, GSK3B, SNORD9, PPARD, CD19, and GPM6B, among others, were upregulated in the pediatric AML cohort (TARGET-AML) (Figure 7c).