The most upregulated genes in adult RUNX1/RUNX1T1-positive AML were RUNX1T1,POU4F1,CACNA2D2,FBLN5, and CAV1, which play a role in axonogenesis, ECM organization, and negative regulation of cell differentiation and ECM assembly. Here, CACNA2D2 is linked to acute myeloid leukemia.