As expected, RUNX1T1, POU4F1, CACNA2D2, FBLN5, and CAV1 were among the top upregulated genes in RUNX1/RUNX1T1 AML patients, followed by CLEC2L, SIPA1L2, GPM6B, CD19, IL5RA, PALM, ITGB4, FAM81A, SLCO5A1, ROBO1, FOXL1, and TRH (Table S1 and Figure 2). This evidence concerns the gene FAM81A and acute myeloid leukemia.