In the adult AML patient cohort (GSE37642), we found that SUZ12, SOX2, EZH2, SMAD4, and STAT3 (among other TFs), as well as MAPK14, CSNK2A1, MAPK1, CDK1, AKT1, and MAPK3 (among other kinases) regulate the co-upregulated genes upstream. Here, SMAD4 is linked to acute myeloid leukemia.