In contrast, in pediatric RUNX1/RUNX1T1 AML, the top upregulated genes were LINC00189, RUNX1T1, M1AP, ADCY7, TPPP3, ADARB1, TSPAN32, GPR114, PALM, SLCO5A1, and HDX. The gene discussed is TPPP3; the disease is acute myeloid leukemia.