We found that apart from RUNX1T1, which is known to be highly expressed in RUNX1/RUNX1T1 AML, POU4F1, CACNA2D2, FBLN5, and CAV1 are also upregulated in adult RUNX1/RUNX1T1 AML patients, followed by CLEC2L, SIPA1L2, GPM6B, CD19, IL5RA, PALM, ITGB4, FAM81A, SLCO5A1, ROBO1, FOXL1, and TRH. The gene discussed is POU4F1; the disease is acute myeloid leukemia.