Previous data indicate that the inhibition of epithelial or stromal SDC2 with SDC2 peptides retards breast tumor growth and metastasis, as well as retraining tumor evasion (via downregulation of TGFβ-regulated programmed death ligand 1 and CXCR4) in a xenograft mouse model [41,58]. This evidence concerns the gene SDC2 and breast neoplasm.