HPSE and breast carcinoma: They demonstrated that SDC4 is a direct target of miR-140-3p, whose overexpression phenocopies the antitumor effects of SDC4 silencing, leading to reduced adhesion, migration, and invasiveness of mammary carcinoma MDA-MB-231, SKBR3, and MCF-7 cells via modulation of FN, FAK, MMP2, and HPSE expression [47].