We determined the expression of NKG2D and NKG2D ligands in intestinal tumorigenesis by comparing their expression pattern in primary tumor and healthy tissue of CRC patients using The Cancer Genome Atlas (TCGA) Colon Adenocarcinoma (COAD) and Colorectal Adenocarcinoma (COADREAD) transcriptomics datasets. The gene discussed is KLRK1; the disease is colorectal carcinoma.