Increased BAFF-R expression supports the BAFF-induced dual-specificity tyrosine phosphorylation-regulated kinase 1a (DYRK1a) kinase-dependent non-canonical NF-κB signaling axis in B-ALL cells, leading to the upregulation of anti-apoptotic Bcl2 and Bcl-xL, and the survival of B-ALL cells [115,146]. The gene discussed is BCL2L1; the disease is acute lymphoblastic leukemia.