UBA2 and cancer: Among the mutated genes, several genes with notable roles in cancer emerged, including several members of the zinc finger family of transcription factors [32] and other molecules related to transcription regulation such as interferon gamma inducible protein 16 (IFI16) [33], important receptors such as erb-b2 receptor tyrosine kinase 4 (ERBB4) and fibroblast growth factor receptor 2 (FGFR2) [34,35], and genes regulating ubiquitination such as autocrine motility factor receptor (AMFR) and ubiquitin-like modifier activating enzyme 2 (UBA2) [36,37].