To investigate whether a specific reduction in MVP, TEP-1, or PARP4 led to cytotoxic or cytoprotective effects, we also performed si-RNA knockdown experiments, which indicated overall that modulation of these components of the vault complex (Figure 2G–K) might have a general influence on cell viability in both tumor models (Figure 2H,J). The gene discussed is PARP4; the disease is neoplasm.