To our knowledge, the only cohort that evaluated SNVs in genes of distinct pathways of CDDP metabolism, damage repair, and apoptosis (GSTM1, GSTT1, GSTP1 c.313A>G, XPC c.2815A>C, XPD c.934G>A, XPD c.2251A>C, XPF c.2505T>C, ERCC1 c.354C>T, MLH1 c.-93G>A, MSH2 c.211 +9G>C, MSH3 c.3133A>G, EXO1 c.1762G>A, P53 c.215G>C, FAS c.-671A>G, FAS c.-1378G>A, FASL c.-844C>T, CASP3 c.-1191A>G, and CASP3 c.-182-247G>T) in the ototoxicity of HNSCC treated with CDDP chemoradiation was previously conducted by our group, and the functional roles of each SNV described in the literature are presented in Table A1. This evidence concerns the gene CASP3 and head and neck squamous cell carcinoma.